STEM CELL & EXOSOME RESEARCH
Explore a curated selection of peer-reviewed studies from leading researchers and medical experts at the forefront of regenerative medicine. These publications highlight groundbreaking advancements in stem cell therapy, tissue engineering, and gene therapies, offering valuable insights into the evolving landscape of innovative healthcare solutions.
Research Categories
Browse peer-reviewed studies organized by condition and specialty.
Osteoarthritis (OA)
Discover how mesenchymal stem cells (MSCs) are advancing regenerative medicine, specifically in the areas of articular cartilage and intervertebral disc repair.
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- Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis
PMC12171193 — Frontiers in Pharmacology, 2025 View Research → - Exosomes Reshape the Osteoarthritic Defect: Emerging Potential in Regenerative Medicine
PMC11612219 — Stem Cell Research, 2024 View Research → - MSC-Derived Exosomes as a Promising Cell-Free Therapy for Knee Osteoarthritis
PMC10824863 — Frontiers in Bioengineering, 2024 View Research → - The Role of Synovial MSC-Derived Exosomes in Cartilage Repair: A Systematic Review
Frontiers in Pharmacology, 2025 View Research → - Intra-Articular Injection of Exosomes from Stem Cells in Animal Models of Osteoarthritis: Systematic Review and Meta-Analysis
Journal of Orthopaedic Surgery and Research, 2024 View Research → - The Future of Osteoarthritis Treatment: ADSC Exosomes — A Scoping Review
PMC12674846 — PubMed Central, 2024 View Research → - Clinical Progress in MSC Therapy: A Focus on Rheumatic Diseases
PMC12067559 — PubMed Central, 2025 View Research → - Recent Developments in Clinical Applications of MSCs for Rheumatoid Arthritis and Osteoarthritis
PMC7982594 — PubMed Central View Research → - From Bench to Bedside: Translating MSC Therapies Through Preclinical and Clinical Evidence
PMC12344367 — Frontiers in Bioengineering, 2025 View Research → - Mesenchymal Stem Cells in Treating Human Diseases: Molecular Mechanisms and Clinical Studies
PMC12371117 — PubMed Central View Research →
Autism
Autologous Cord Blood Infusions Prove Safe and Feasible for Young Children with Autism Spectrum Disorder: Findings from a Single-Center Phase I Open-Label Trial
Rheumatoid Arthritis / Polymyalgia Rheumatica (OA/PMR)
Autologous Stromal Vascular Fraction Cells: A Potential Tool for Promoting Tolerance in Rheumatic Diseases.
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- Human MSCs for Treatment of Immune and Inflammation-Mediated Diseases: Review of Current Clinical Trials
PMC5095977 — PubMed Central View Research → - Modular Mastery of Inflammation: Umbilical Cord MSCs as a Therapeutic Frontier
PMC12757260 — Frontiers in Immunology, 2025 View Research → - MSCs: Environmentally Responsive Therapeutics for Regenerative Medicine
PMC3849579 — PubMed Central View Research →
Post Cancer Chemotherapy
Adult Mesenchymal Stem Cells in the Treatment of Radiation Injury
Anti-Aging
Cellular Reprogramming-Based Strategies for Anti-Aging
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- Therapeutic Applications of Stem Cell-Derived Exosomes
PMC10971636 — PubMed Central View Research → - Frontier Review of the Molecular Mechanisms and Current Approaches of Stem Cell-Derived Exosomes
PMC10093591 — Cells, 2023 View Research → - Clinical Application of MSCs in Regenerative Medicine: A Narrative Review
PMC9330677 — Stem Cell Research and Therapy, 2022 View Research →
In Conjunction with Surgical Treatment
Studies on bone marrow aspirate and platelet-rich plasma combined with surgical techniques.
- Fortier LA, et al. (2010) Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in an equine model. Link →
- Milano G, et al. (2010) The effect of platelet rich plasma combined with microfractures on the treatment of chondral defects. Link →
- Buda R, et al. (2015) One-step bone marrow-derived cell transplantation in talar osteochondral lesions. Link →
Meniscus or Ligament Injuries
Research on PRP and mesenchymal stem cells for ligament and meniscal healing.
- Foster TE, et al. (2009) Platelet-rich plasma: from basic science to clinical application. Link →
- Murray MM, et al. (2009) Enhanced histologic repair in a central wound in the anterior cruciate ligament. Link →
- Braun HJ, et al. (2013) The Use of PRP in ligament and meniscal healing. Link →
- Yu H, et al. (2015) Meniscus repair using mesenchymal stem cells. Link →
- Cook JL, et al. (2016) Multiple injections of leukoreduced platelet rich plasma. Link →
Muscle and Tendon Injuries — Lateral Epicondylitis
Studies on platelet-rich plasma for chronic tennis elbow and lateral epicondylitis.
- Peerbooms JC (2010) Positive effect of an autologous platelet concentrate in lateral epicondylitis. Link →
- Gosens T, et al. (2011) Ongoing positive effect of platelet-rich plasma versus corticosteroid injection. Link →
- Mishra A, et al. (2014) Efficacy of platelet-rich plasma for chronic tennis elbow. Link →
Patellar Tendonitis
Research on PRP and bone marrow stem cells for patellar and Achilles tendinopathy.
- Cervellin M, et al. (2012) Autologous platelet-rich plasma gel to reduce donor-site morbidity. Link →
- Di Matteo B, et al. (2015) Platelet-rich plasma: evidence for the treatment of patellar and Achilles tendinopathy. Link →
- Pascual-Garrido C, et al. (2012) Treatment of chronic patellar tendinopathy with autologous bone marrow stem cells. Link →
Rotator Cuff Tears
PRP and mesenchymal stem cell augmentation for rotator cuff repair.
Achilles Tendinopathy
Platelet-rich fibrin and bone marrow aspirate for Achilles tendon repair.
Fractures
Intramedullary nailing combined with platelet-rich plasma for non-union fractures.
- Galasso O, et al. (2008) Expandable intramedullary nailing and platelet rich plasma to treat long bone non-unions. Link →
Bursitis
PRP injection grafts for musculoskeletal injuries including bursitis.
- Sampson S, et al. (2008) Platelet rich plasma injection grafts for musculoskeletal injuries. Link →
Cosmetic Surgery
PRP applications in plastic surgery, skin rejuvenation, and acne scar treatment.
- Man D, et al. (2001) The use of autologous platelet-rich plasma in cosmetic surgery. Link →
- Cervelli V, et al. (2009) Application of platelet-rich plasma in plastic surgery. Link →
- Redaelli A, et al. (2010) Face and neck revitalization with platelet-rich plasma. Link →
- Sclafani AP, and SA McCormick (2012) Induction of dermal collagenesis, angiogenesis, and adipogenesis in human skin. Link →
- Lee JW, et al. (2011) Efficacy of autologous platelet rich plasma combined with ablative CO₂ fractional resurfacing for acne scars. Link →
- Cho JM, et al. (2011) Effect of platelet-rich plasma on ultraviolet b-induced skin wrinkles in nude mice. Link →
- Shin MK, et al. (2012) Platelet-rich plasma combined with fractional laser therapy for skin rejuvenation. Link →
Spine
Bone marrow concentrate and PRP injections for discogenic back pain.
- Pettine K, et al. (2015) Percutaneous Injection of Autologous Bone Marrow Concentrate Cells Significantly Reduces Lumbar Discogenic Pain. Link →
- Pettine K, et al. (2016) Treatment of discogenic back pain with autologous bone marrow concentrate injection. Link →
- Monfett M, et al. (2016) Intradiscal platelet-rich plasma injections for discogenic low back pain. Link →
Wound Care
PRP and mesenchymal stem cells for chronic wounds, diabetic foot ulcers, and trauma.
- Hom DB, et al. (2007) The healing effects of autologous platelet gel on acute human skin wounds. Link →
- Driver VR, et al. (2006) A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for diabetic foot ulcers. Link →
- Kazakos K, et al. (2009) The use of autologous PRP gel as an aid in the management of trauma wounds. Link →
- Carter MJ, et al. (2011) Use of platelet-rich plasma gel on wound healing: a systematic review and meta-analysis. Link →
- Saad Setta H, et al. (2011) Platelet-rich plasma versus platelet-poor plasma in management of chronic diabetic foot ulcers. Link →
- Dabiri G, et al. (2013) The emerging use of bone marrow-derived mesenchymal stem cells for chronic wounds. Link →
- Efficacy of MSCs and PRP Therapies on Wound Healing: Systematic Review and Meta-Analysis
PMC12148411 — PubMed Central, 2025 View Research → - Adipose MSCs Combined with PRP Accelerate Diabetic Wound Healing via the Notch Pathway
PMC8276220 — PubMed Central View Research → - MSCs Promote Wound Healing and Effects on MMP-8 and MMP-9 in Diabetic Rats
PubMed 36322784 — Stem Cells and Development, 2023 View Research → - The Potential of MSCs in Diabetic Wounds: Is It Time for Use in Everyday Practice?
MDPI International Journal of Molecular Sciences, 2024 View Research → - Advancing Regenerative Therapies with Umbilical Cord-Derived MSCs: A Review
PMC12710621 — Biomolecules and Biomedicine, 2025 View Research →
Oral and Maxillofacial Surgery
PRP and platelet-rich fibrin in periodontal and maxillofacial procedures.
- Marx RE. Platelet-rich plasma: evidence to support its use. Link →
- Sammartino G, et al. (2005) Use of autologous platelet-rich plasma in periodontal defect treatment. Link →
- Bajaj P, et al. (2013) Comparative evaluation of autologous platelet-rich fibrin and platelet-rich plasma in mandibular furcation defects. Link →
Peripheral Vascular Disease
Bone marrow cell therapy for peripheral arterial disease and critical limb ischemia.
- Tateishi-Yuyama E, et al. (2002) Therapeutic angiogenesis for patients with limb ischemia. Link →
- Bartsch T, et al. (2007) Transplantation of autologous mononuclear bone marrow stem cells in patients with peripheral arterial disease. Link →
- Amann B, et al. (2009) Autologous bone marrow cell transplantation increases leg perfusion. Link →
- Molavi B, et al. (2016) Safety and Efficacy of Repeated Bone Marrow Mononuclear Cell Therapy in Critical Limb Ischemia. Link →
Neurological and Cognitive Support
Emerging research on MSC and exosome therapies for neurorestoration, cognitive function, and neurocognitive support.
- Emerging Role of MSC and Exosome Therapies in Treating Cognitive Impairment
PMC11945939 — Pharmaceutics, 2025 View Research → - Exosomes as a Therapeutic Tool to Promote Neurorestoration and Cognitive Function
PMC11110007 — CNS Neuroscience and Therapeutics, 2024 View Research → - MSC-Derived Exosomes as New Remedy for the Treatment of Neurocognitive Disorders
PMC7867043 — International Journal of Molecular Sciences, 2021 View Research → - MSC-Derived Exosomes Ameliorate Alzheimer's Disease Pathology and Improve Cognitive Deficits
PMC8225157 — PubMed Central View Research → - MSC-Derived Exosomes Improve Neurogenesis and Cognitive Function: A Novel Treatment Approach
PMC11116483 — CNS Neuroscience and Therapeutics, 2024 View Research → - Exosome-Based Neurotherapeutic Drug Delivery and Blood-Brain Barrier Penetration
PubMed 38642716 — European Journal of Pharmaceutics and Biopharmaceutics, 2024 View Research →
Cardiovascular Support
Research exploring stem cell-derived exosomes and their potential therapeutic roles in cardiovascular health.
- Stem Cell-Derived Exosomes: Potential Therapeutic Roles in Cardiovascular Diseases
PMC8382889 — Frontiers in Cardiovascular Medicine, 2021 View Research →
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